As Iddo pointed out on Twitter, sequencing the DNA from GFAJ-1 is itself strong evidence against arsenate in the DNA backbone, since the sequencing chemistry would be highly unlikely to work in that case. However, if like me you think that a new microbial genome provides the most fun to be had in bioinformatics [*], you’ll be excited by the availability of the data.
In this post then: where to get it, some very preliminary analysis and some things that you might like to to with it. Projects for your students, perhaps.
[*] note to self: why, then, am I working on colorectal cancer?
Read the rest…