Mysteries of vitamin B12

In a former, pre-bioinformatics life, I described myself as a biochemist. Once in a while, biochemistry news still catches my eye. A paper in this weeks Nature describes the structure and function of the BluB gene product from S. meliloti which, it turns out, is the missing enzymatic link in vitamin B12 biosynthesis.

I suspect there was a fair amount of bioinformatic evidence that led them to BluB, but it’s not detailed in the paper. Still, it’s a fascinating molecule with a long, rich research history (4 Nobel prizes are for vitamin B12 research).