In general, I don’t find the Careers section in Nature very helpful. It often features rather general, obvious advice such as “acquiring new skills is good”, then fails to expand further. Once in a while though, there is a longer more helpful article and these are more popular, judging by the hits. The top two articles for last December are:
Should I stay or should I go?
Gut check time: should you stay in academia, on the bench or even quit science?
How to ask yourself questions about major career decisions.
Which says rather a lot, I think.